在COVID-19疫苗接种期间SARS-CoV-2变种的临床严重性:系统性审查和元分析
Zhilu Yuan1, Zengyang Shao2, Lijia Ma2
1School of Architecture and Urban Planning, Research Institute for Smart Cities, Shenzhen University, Shenzhen 518060, China.
Viruses
|October 28, 2023
概括
SARS-CoV-2的三角洲变种显示出COVID-19的严重程度最高,而Omicron的严重程度最低. 65岁以上的老年人在所有指标上都经历了更高的严重程度.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 由于SARS-CoV-2变种,COVID-19的严重程度有很大差异,使资源分配和公共卫生干预复杂化.
- 准确的临床严重性数据对于风险评估,传播建模和流行病控制策略至关重要.
研究的目的:
- 在大规模疫苗接种期间,系统地审查和元分析COVID-19变种的临床严重性指标.
- 为确认病例-住院,病例-死亡,住院-死亡和住院-ICU风险提供综合估计.
主要方法:
- 从2020年1月到2022年2月在PubMed上发表的研究的系统审查和元分析.
- 搜索临床严重性数据,包括住院,ICU入院和与不同COVID-19变种相关的死亡风险.
- 包括13项研究在选3536个初始记录后.
主要成果:
- 德尔塔变种的临床严重程度最高 (6.56%住院,0.46%死亡,19.63%住院至死亡,9.06%住院至ICU).
- 奥米克朗变种的严重程度最低 (1.51%的住院,0.04%的死亡,6.01%的住院至死亡,3.18%的住院至ICU).
- 65岁以上的成年人在所有评估指标上始终表现出更高的严重程度.
结论:
- COVID-19 变种的演变显著影响了临床严重程度,其中三角形是最严重的,而Omicron 最不严重.
- 年龄是一个关键因素,老年人面临更高的风险.
- 调查结果为公共卫生政策和资源管理提供了信息,以应对流行病.
更多相关视频
08:41Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
2.8K
10:25Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
4.7K
相关概念视频
02:50Conjugated Proteins
18.3K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.3K
01:05Single Nucleotide Polymorphisms-SNPs
15.2K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.2K
01:51Vaccinations
44.6K
Overview
44.6K
01:29Bias in Epidemiological Studies
314
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
314
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
133
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
133