免疫特征决定了移植患者对COVID-19疫苗接种的反应
Stamatia Stai1,2, Asimina Fylaktou3, Efstratios Kasimatis1,2
1School of Medicine, Aristotle University of Thessaloniki, 45642 Thessaloniki, Greece.
Vaccines
|October 28, 2023
概括
对第三剂Tozinameran (BNT162b2) 疫苗有反应的移植接受者 (KTRs) 的基线免疫细胞计数不同. 他们的细胞免疫特征在接种疫苗后发生了显著的变化,表明了不同的免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 移植科学 移植科学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 免疫状况预测了接种疫苗的反应.
- 淋巴细胞表型表明疫苗的有效性.
- 移植接受者 (KTRs) 需要评估COVID-19疫苗接种的有效性.
研究的目的:
- 在接种Tozinameran (BNT162b2) 疫苗后,对KTRs的免疫状态和淋巴细胞表型进行前性评估.
- 在KTRs中确定预测疫苗反应的免疫参数.
- 为了比较响应者与不响应者在第三剂疫苗接种后的免疫特征.
主要方法:
- 对39名成年KTR进行前性,单中心的观察性研究.
- 在接种两剂疫苗后,KTRs具有免疫抑制,COVID-19天真,并且缺乏幽默反应.
- 在基线,第三剂前和第三剂后三周评估的幽默和细胞免疫力.
主要成果:
- 与非响应者相比,响应者具有较高的基线总和过渡性B淋巴细胞计数.
- 在响应者中,激活的CD4+和CD8+T细胞增加,而CD3+PD1+T细胞从疫苗接种前到疫苗接种后减少.
- 原始和过渡性B细胞在响应者中的第三剂疫苗后显著增加.
结论:
- 第三次BNT162b2剂量的反应者和不反应者表现出不同的基线免疫细胞简介.
- 疫苗接种引起了细胞亚种群在响应KTRs时的显著变化.
- 免疫细胞概况可以在KTRs中区分疫苗反应.
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