对于成年人进行固体器官移植的候选人和接受者的疫苗接种建议
Mauro Viganò1, Marta Beretta2, Marta Lepore3
1Gastroenterology Hepatology and Transplantation Unit, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
Vaccines
|October 28, 2023
概括
疫苗接种对于固体器官移植 (SOT) 候选人和接受者至关重要,以预防感染. 由于移植后免疫反应减少,建议在移植前达到最佳的疫苗接种状态.
科学领域:
- 免疫学 免疫学 免疫学
- 移植医学 移植医学 移植医学
- 预防传染病 预防传染病
背景情况:
- 固体器官移植 (SOT) 候选人和接受者面临器官缺陷和免疫抑制导致的感染风险增加.
- SOT患者的感染可能导致严重的发病率,死亡率,并危及移植的生存.
- 在免疫抑制的移植群体中,标准的抗微生物治疗效果较差.
研究的目的:
- 审查当前关于成人SOT候选人和接种者的疫苗接种指示和方案的数据.
- 强调移植前疫苗接种对于最佳免疫反应和感染预防的重要性.
主要方法:
- 对SOT候选人和接种者的疫苗接种现有数据的文献综述.
- 对当前在这个人群中接种疫苗的建议和方案的分析.
主要成果:
- 接种疫苗是对SOT患者感染的关键预防策略.
- 对疫苗的免疫反应通常会减弱,特别是在移植后的早期或排斥治疗后.
- 移植前的疫苗接种对于在免疫抑制加剧之前建立足够的免疫力至关重要.
结论:
- 在SOT之前优化疫苗接种状态对于患者安全和移植结果至关重要.
- 遵守特定的疫苗接种计划对于管理这种脆弱群体的传染风险至关重要.
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