相关实验视频

Updated: Jul 12, 2025

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

用于RNA治疗的N-乙糖氨酸输送系统:一个专利前景

Hai-Long Zhang¹, Lansuo Wang¹

¹Central International Intellectual Property (Baotou) Co. Ltd, Baotou, China.

Expert opinion on therapeutic patents

|October 28, 2023

概括

这项研究利用专利数据绘制了N-乙银胺 (GalNAc) -RNA疗法的修改和治疗用途. 它确定了8个主要和5个新的修改,以及肝脏疾病和癌症治疗等关键应用.

科学领域:

生物技术是生物技术.
药物发现药物发现药物发现
在RNA治疗方面,RNA疗法.

背景情况:

小干扰RNA (siRNA) 对基于RNA干扰的药物发现至关重要.
N-乙银胺 (GalNAc) -RNA疗法在基于RNA的治疗中是一个快速发展的领域.

研究的目的:

分析GalNAc-RNA疗法的专利环境.
绘制GalNAc-RNA剂的修改和治疗应用的地图.

主要方法:

分析2004年1月至2023年4月美国授予的专利.
专利数据分析以确定修改特征和治疗应用.

主要成果:

在GalNAc-RNA疗法中发现了8个主要和5个新出现的修改.
突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出
在肝脏疾病,癌症,高脂血症和神经疾病中有系统地证明了治疗应用.

结论:

本专利分析提供了关于GalNAc-RNA治疗修改和应用的全面概述.
这些发现提供了对RNA疗法的不断变化的景观及其潜在的临床用途的见解.

关键词:

这就是GalNAcc.这就是GalNAc-RNA.这是一种N-乙银胺胺.这是一个RNARNARNARNARNA.patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent

更多相关视频

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

Published on: June 10, 2022

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

相关概念视频

Experimental RNAi

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...

Regulated mRNA Transport

Regulated mRNA Transport

Oligosaccharide Assembly

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...

RNA Interference

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...