circRNADisease v2.0:为高质量的实验支持的 circRNA-疾病关联提供最新资源
Zhi-Yan Sun1,2, Chang-Lin Yang1, Li-Jie Huang1
1Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China.
Nucleic acids research
|October 28, 2023
概括
现在,circRNADisease 2.0数据库将数千个圆形RNA (circRNA) 与12个物种的许多疾病联系起来. 这种增强的资源有助于研究人员理解circRNA在复杂疾病中的作用.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 分子生物学分子生物学
背景情况:
- 循环RNAs (circRNAs) 越来越多地被认为是它们在疾病发病过程中的作用.
- 现有的circRNA疾病关联数据库需要扩展和增强,以支持全面的研究.
- 以前,circRNADisease数据库提供了关于circRNA与疾病关系的有价值但有限的数据.
研究的目的:
- 介绍更新和扩展的circRNADisease 2.0数据库,提供显著更大,更详细的实验验证的circRNA疾病关联的集合.
- 纳入新的数据类型,包括circRNA相关的因素,分子机制,生物功能和临床相关性,以提供整体的观点.
- 促进研究circRNAs与疾病之间的复杂相互作用.
主要方法:
- 来自不同来源的精选和整合经过实验验证的circRNA疾病关联数据.
- 扩展了数据库,包括12种物种,4246个circRNA和330种疾病类型,导致6998条条目.
- 新增了针对circRNA相关因素,分子机制,生物功能,临床数据和突变-circRNA关系的新模块.
主要成果:
- circRNADisease 2.0包含6998个circRNA疾病条目,比上一个版本增加了19.77倍.
- 该数据库现在涵盖12种物种,包括有关因素,途径,功能和临床数据的详细信息.
- 在30种TCGA癌症类型中确定了7,159,865种突变-circRNA关系.
结论:
- 增强的circRNADisease 2.0数据库为研究疾病中的circRNA功能提供了无价的,全面的资源.
- 它的大量数据和新功能支持基础研究和潜在的临床应用.
- 有助于更深入地了解circRNA对复杂疾病和相关突变的影响.
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