一个全面的预后得分头部和部状癌症驱动基因和表型特征的综合预后得分
Wen Zeng1, Fangfang Xie2, Yiyun Pan1
1Ganzhou Cancer Hospital, Gannan Medical College Affiliated Cancer Hospital, No.19, Huayuan Road, Zhanggong Avenue, Ganzhou, Jiangxi, People's Republic of China.
Discover oncology
|October 28, 2023
概括
一个新的准确预测模型的头部和部状细胞癌总生存率 (APMHO) 整合了基因表达和临床数据来预测患者的生存率. 这种模型有助于了解瘤特征和头癌的免疫治疗反应.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 头部和部状细胞癌 (HNSCC) 表现出不同的表型和进展模式.
- 准确的预后模型对于HNSCC生存预测至关重要.
- 整合分子和临床数据可以提高预后准确性.
研究的目的:
- 开发一个全面的HNSCC整体存活预后工具.
- 将癌症驱动基因与临床和表型信息相结合,以改善预测.
- 创建HNSCC整体生存得分 (APMHO) 的准确预测模型.
主要方法:
- 使用TCGA数据和Cox回归,选了与整体生存相关的癌症驱动基因.
- 使用GSE41613数据集验证了关键基因.
- 开发了一个转录组分数,并将其与临床变量 (年龄,阶段) 结合起来,构建和验证APMHO模型.
主要成果:
- 确定了6个关键基因 (CRLF2,HSP90AA1,MAP2K1,PAFAH1B2,MYCL,SET) 并开发了一个转录分数.
- 综合年龄,阶段和转录分数的APMHO模型显示出强大的预后能力 (AUC>0.65).
- 高APMHO分数与突变率增加,瘤途径丰富 (低氧,糖解) 和独特的免疫特征相关.
结论:
- 通过整合转录和临床数据,APMHO评分有效预测HNSCC总生存率.
- APMHO与瘤表型,免疫格局和免疫治疗敏感性的变化有关.
- 建议在独立的临床队列中进一步验证.
相关概念视频
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.5K
01:33Cancer-Critical Genes I: Proto-oncogenes
8.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.9K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
01:21Cancer Survival Analysis
357
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
357