探索利益相关者对实施大肠直肠癌普遍生殖基因检测的观点:从临床实践调查中得出的发现
Linda Rodgers-Fouche1, Sanjeevani Arora2, Charité Ricker3
1Center for Cancer Risk Assessment, Massachusetts General Hospital, Boston, MA.
JCO precision oncology
|October 28, 2023
概括
对结直肠癌 (CRC) 的普遍生殖基因检测 (UGT) 在专家中得到了强烈支持. 然而,为了成功实施,需要解决诸如提供者知识和保险覆盖等挑战.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 医疗保健政策 医疗保健政策
背景情况:
- 新的指导方针建议对所有结直肠癌 (CRC) 患者进行生殖基因检测.
- 利益相关者对普遍生殖线检测 (UGT) 实施的看法没有得到充分的证据.
- 了解这些观点对于有效采用指南至关重要.
研究的目的:
- 评估美洲遗传性胃肠癌协作小组 (CGA-IGC) 成员对CRC的UGT实施的观点.
- 确定UGT的准备,后勤考虑和障碍.
- 为将UGT整合到临床实践中的战略提供信息.
主要方法:
- 对317名活跃的CGA-IGC成员进行了一项横截面调查.
- 该调查收集了有关人口统计,临床实践,当前测试协议和UGT实施的数据.
- 响应率为25% (80名参与者).
主要成果:
- 73%的参与者支持UGT,但54%的人指出需要改变实践.
- 关键障碍包括非遗传学提供者之间有限的遗传学知识,同意/披露流程和保险覆盖.
- 大多数人支持标准化的多基因小组和非遗传学提供者的参与.
结论:
- 遗传性胃肠道癌症专家广泛支持UGT用于CRC患者.
- 涉及非遗传学供应商的替代服务提供模式对于克服后勤障碍至关重要.
- 解决这些障碍对于满足日益增长的基因测试需求至关重要.
更多相关视频
10:13A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
Published on: July 3, 2013
11.2K
07:59Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
1.1K
相关概念视频
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.5K
