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光线和三阴性乳腺癌与HER2低蛋白表达的特征

Nehal M Atallah¹, Maria Haque², Cecily Quinn³

¹Translational Medical Science, School of Medicine, the University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK; Department of Pathology, Faculty of Medicine, Menoufia University, Egypt.

European journal of cancer (Oxford, England : 1990)

|October 28, 2023

概括

HER2低乳腺癌 (BC) 大多是激素受体阳性 (HR+) 和类似于HER2-负的BC. 然而,HR阴性HER2低BC显示出一个独特的光雄激素受体 (LAR) 亚型,具有独特的免疫特征和更好的生存率.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
免疫学免疫学免疫学

背景情况:

人类表皮生长因子受体2 (HER2) 低乳腺癌 (BC) 是一种新兴的亚型,需要进一步表征.
了解HER2低BC的临床病理和分子特征对于完善治疗策略至关重要.

研究的目的:

为了全面描述HER2低BC.
在辅助和新辅助环境中调查治疗反应和患者的治疗结果.
阐明HER2低BC的分子和免疫特征.

主要方法:

分析了两个独立的BC队列:诺丁汉 (n=5744) 和癌症基因组图谱 (TCGA) (n=854).
研究临床,分子,生物和免疫学概况.
对TCGA队列进行的转录组和途径丰富分析,在诺丁汉队列中得到验证.

主要成果:

90%的HER2低瘤是激素受体阳性 (HR+),光线亚型,与HER2-阴性BC相比,预后没有显著差异.
在HR阴性BC中,HER2低瘤的攻击性较低,与更长的存活率相关,并且主要属于光类受体 (LAR) 亚型.
HR-/HER2低瘤表现出独特的免疫特征,富含T辅助淋巴细胞,树突细胞和中性粒细胞,与基底类HR-/HER2-瘤不同.

结论:

在HR+瘤中,HER2低BC主要由HR信号驱动.
HR阴性HER2低BC的特点是LAR亚型和独特的免疫微环境.

关键词:

乳腺癌乳腺癌乳腺癌网络竞技网络竞技 HER2 低低低内在的分子亚型内在的分子亚型转录组分析转录组分析

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