蓝藻细菌繁殖和抗生素耐药基因之间的相互作用
Min-Ji Kim1, Dayun Kang2, GyuDae Lee1
1Department of Applied Biosciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Environment international
|October 28, 2023
概括
蓝藻有害藻类的繁殖减少了抗生素耐药性基因 (ARG) 通过超越细菌. 然而,这些花朵增加了移动基因元素和毒性因素,突出显示了微生物失生症的风险.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 生态毒理学 生态毒理学
背景情况:
- 淡水菌有害藻类繁殖 (cyanoHABs) 是一个日益严重的环境和公共卫生问题.
- 淡水生态系统含有抗生素耐药性基因 (ARG),在微生物失生症 (如蓝藻HABs) 期间存在传播风险.
- 污染物,蓝色HAB和ARG之间的相互作用尚未得到充分理解.
研究的目的:
- 在淡水环境中研究蓝色HAB和ARG之间的关系.
- 探索蓝藻细菌竞争对ARG动态的影响.
- 为了了解蓝色HABs如何影响移动基因元素和毒性因子.
主要方法:
- 在cyanoHABs期间对9个河流地区进行采样.
- 微生物组,抵抗体和移动体组成的分析.
- 微生物群落,ARG,物理化学性质和蓝色HAB严重程度之间的相关性分析.
主要成果:
- 在cyanoHABs期间,微囊和高微囊水平占主导地位.
- 抵抗性,移动性和微生物组相互连接,并受到水特性的影响.
- 菌与携带ARG的细菌 (Actinobacteriota,Proteobacteria) 竞争,从而降低了ARG水平.
- 尽管ARG减少了,但在cyanoHAB压力下,移动基因元素和毒性因子增加了.
结论:
- 菌通过与本地细菌竞争,积极塑造淡水抗体.
- 矛盾的是,cyanoHABs可以降低ARG,同时增加其他遗传风险 (MGE,VF).
- 预防微生物失生症对于管理水生生态系统中ARG风险至关重要.
相关概念视频
00:57Antibiotic Selection
54.5K
Overview
54.5K
01:30Development of Antibiotic Resistance
17
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
17
01:30Bacterial Phylum Cyanobacteria
27
Cyanobacteria are a diverse group of oxygenic, phototrophic bacteria that played a pivotal role in converting Earth’s atmosphere from anoxic to oxygen-rich billions of years ago. They exhibit remarkable morphological diversity, ranging from unicellular forms to filamentous types, with cell sizes varying between 0.5 μm and 100 μm. Cyanobacteria are classified into five groups: Chroococcales (unicellular, dividing by binary fission), Pleurocapsales (unicellular, dividing by...
27
01:28Gene Regulation in Microbial Communities: Quorum Sensing
23
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
23
00:46Genomic DNA in Prokaryotes
43.9K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.9K
01:26Transformation
15
Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
15