在晚期癌症的老年人中可修改的跌倒风险因素:一个集群随机临床试验的二次分析
Marielle Jensen-Battaglia1, Mostafa Mohammed1, Kah Poh Loh2
1Division of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA; Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
患有晚期癌症的老年人面临着独特的跌倒风险. 以前的跌倒和运动障碍是关键的可修改因素,与未来的跌倒有关.
科学领域:
- 老年瘤学 老年瘤学
- 癌症患者的安全
- 防摔研究 防摔研究
背景情况:
- 患有癌症的老年人由于疾病和多药和神经毒性疗法等治疗方法而存在独特的跌倒风险.
- 识别可修改的风险因素对于在这个脆弱人群中预防跌倒至关重要.
研究的目的:
- 确定与晚期癌症的老年人未来跌倒相关的可修改的风险因素.
- 在六个月的随访期内分析跌倒发生率.
主要方法:
- 来自COACH研究数据的二次分析 (NCT02107443).
- 包括70岁以上的患者,患有III/IV期固体瘤或淋巴瘤和老年评估损伤,接受息治疗.
- 跌倒是自我报告的,并使用逆概率权重来调整通用线性混合模型中的死亡率.
主要成果:
- 之前的跌倒 (基线为26%) 和受损的时间上升和上升 (TUG) 评分与六个月内更高的跌倒发病率显著相关.
- 在541名患者中,22%的人在随访期间报告至少一次跌倒.
- 24%的人因死亡而没有完整的随访.
结论:
- 以前的跌倒和受损的TUG分数是晚期癌症的老年人中显著的,潜在的可修改的跌倒风险因素.
- 建议将跌倒风险评估和干预措施整合到癌症治疗中,以减少这一群体的跌倒.
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