在严重的支气管肺功能障碍症中进行胸部计算机断层扫描:比较定量评分方法
S Fontijn1, S J A Balink2, M Bonte2
1Post-graduate School of Paediatrics, University of Modena and Reggio Emilia, Modena, Italy.
European journal of radiology
|October 28, 2023
概括
手动的霍恩斯菲尔德单位 (HU) 方法和PRAGMA-BPD得分显示出在支气管肺功能失调 (BPD) 中量化肺损伤的出色可重复性. 这些方法准确地评估BPD婴儿的CT异常.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 新生儿科学 新生儿科学
背景情况:
- 支气管肺功能障碍症 (BPD) 是极度早产婴儿的常见并发症,通常与肺部结构异常有关.
- 在BPD中精确量化肺损伤对于患者管理和研究至关重要.
研究的目的:
- 评估基于Hounsfield单位 (HU) 的三种新的胸部CT评分方法,用于量化BPD肺损伤.
- 评估这些方法的观察者内部和观察者间的变异性.
- 为了将HU方法与已建立的珀斯-罗德曼-注释-网格-形态学分析 (PRAGMA) -BPD得分和临床数据进行比较.
主要方法:
- 从患有严重BPD的婴儿的胸部CT扫描被分析在7个月的中位数纠正年龄.
- 使用PRAGMA-BPD和三种基于HU的方法 (自动化,半自动化,手动) 进行过度和低衰减区域的量化.
- 使用类内相关系数 (ICC) 和布兰德-阿尔特曼图表评估可重复性;使用斯皮尔曼等级相关性评估与临床数据的相关性.
主要成果:
- 手动HU方法和PRAGMA-BPD显示出优异的观察者内部和观察者之间的可重复性 (ICCs 0.80-0.97).
- 手动的HU方法显示了与PRAGMA-BPD在超 (ρ=0.92) 和低衰减 (ρ=0.79) 两方面都有很高的相关性.
- 自动化和半自动化HU方法的相关性较差,特别是在低衰减方面.
结论:
- 手动霍恩斯菲尔德单位 (HU) 方法和PRAGMA-BPD得分为量化BPDCT异常提供了最佳的可重现性.
- 这些发现支持使用手动HU方法作为评估BPD肺损伤的可靠工具.
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