一个完全卷积的神经网络,用于MRI中腹部脂肪组织区的全面细分
Yeshe M Kway1, Kashthuri Thirumurugan2, Navin Michael2
1Singapore Institute for Clinical Sciences, Agency for Science Technology, and Research, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Computers in biology and medicine
|October 28, 2023
概括
这项研究开发了一个卷积神经网络,用于使用MRI精确的腹部脂肪组织 (AAT) 亚仓库细分. 人工智能模型准确地区分了表面皮下脂肪 (SSAT),深部皮下脂肪 (DSAT),腹膜内脂肪 (IPAT),腹膜后脂肪 (RPAT) 和脊椎侧脂肪 (PSAT) 的脂肪储存.
科学领域:
- 医学成像分析分析 医学成像分析
- 医学中的人工智能.
- 肥胖研究的研究.
背景情况:
- 腹部脂肪组织 (AAT) 亚存储处表现出明显的结构,生理和病理特征.
- 准确量化AAT分库对于了解肥胖及其相关的并发症至关重要.
- 目前用于AAT分仓分离和定量化的方法是具有挑战性的,原因是医学成像和复杂,耗时的过程中不清楚的界限.
研究的目的:
- 实施和评估一个卷积神经网络 (CNN),以对AAT进行细分评估.
- 将皮下脂肪组织 (SAT) 分为表面皮下脂肪组织 (SSAT) 和深部皮下脂肪组织 (DSAT).
- 将内脏脂肪组织 (IAT) 分为腹腔内脂肪组织 (IPAT),腹腔内脂肪组织 (RPAT) 和侧脊脂肪组织 (PSAT).
主要方法:
- 来自新加坡预孕研究长期母亲和儿童结果 (S-PRESTO) 和新加坡成人新陈代谢研究 (SAMS) 的MRI数据集的回顾性收集.
- 对所有数据集进行地面真相面具的手动细分.
- 基于Res-Net的3D-UNet模型的培训和评估,使用S-PRESTO数据的5倍交叉验证,并对保留和外部测试集进行最终评估.
主要成果:
- 美国有线电视新闻网 (CNN) 在个别的AAT分仓细分上获得了高平均子相似度得分:SSAT为98.3%,DSAT为97.2%,IPAT为96.5%,RPAT为96.3%,PSAT为95.9%.
- 在3DMRI卷中证明了SSAT,DSAT,IPAT,RPAT和PSAT的可靠细分.
结论:
- 卷积神经网络可以准确地将腹部SAT和IAT分为各自的存储库 (SSAT,DSAT,IPAT,RPAT,PSAT) 以高精度.
- 开发的方法在推进肥胖成像和精准医学应用方面具有重大潜力.
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