从怀孕中期到围产期的人类骨髓弧形核的发展:一种形态测量研究
Katsuyuki Yamaguchi1, Takuya Yazawa1
1Department of Pathology, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan.
Neuroscience letters
|October 28, 2023
概括
人类骨髓弧形核 (AN) 发育在胎儿时期显示出显著的不对称性和个体变异性. 神经元死亡和生产在妊娠中期后同时发生.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 人类解剖学 人类解剖学
背景情况:
- 人类骨髓弧形核 (AN) 的发展尚不清楚.
- 这项研究研究了早产和围产婴儿中AN的形态.
研究的目的:
- 在胎儿发育过程中提供人类骨髓弧形核 (AN) 的形态学数据.
- 分析AN的体积,神经元密度,神经元总数和神经元配置面积.
主要方法:
- 研究了9个21-43个月经后周 (PW) 的婴儿大脑.
- 使用了用Klüver-Barrera染色的序列细胞因素部分.
- 进行了AN的形态测量分析,包括神经元数量和体积.
主要成果:
- 该AN呈现为配对的神经元质量,与位置相对于金字塔管 (PT).
- 随着年龄的增长,神经元的尺寸会增加,呈现出各种不同的形状.
- 在AN体积,神经元总数和平均神经元配置面积方面观察到显著的不对称性和个体变异性.
结论:
- 人类骨髓弧形核 (AN) 形态在胎儿时期显示出显著的不对称性和个体变异性.
- 在怀孕中期后,AN可能会同时经历神经元死亡和神经细胞细胞的产生.
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