相关实验视频

Updated: Aug 13, 2026

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

快速酵素活性模型 (REAM) 解读了基和多基物质的毒性作用

Precious Obiako¹, Amanda Sevcik¹, Christie M Sayes¹

¹Department of Environmental Science, Baylor University, Waco, TX, 76798, USA.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|October 28, 2023

概括

一种新的快速酶活性模型 (REAM) 提供了一种快速,廉价,无细胞的方法来选新出现的污染物,如和多基物质 (PFAS),并了解它们对人类健康的有毒影响.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
生物化学生化学

背景情况:

和多醇基物质 (PFAS) 是由于人类广泛暴露而引起重大公共卫生关注的新兴污染物.
了解PFAS和其他环境化学品的毒性机制对于风险评估至关重要.

研究的目的:

开发和展示一种新的快速酶活性模型 (REAM) 作为一种无细胞查工具.
提供一种廉价和快速的方法来阐明环境化学品 (包括PFAS) 的潜在毒性作用机制.

主要方法:

开发基于酶活性的无细胞选试验.
应用REAM用于对环境相关化学品进行快速评估.

主要成果:

该REAM为化学选提供了一种快速且具有成本效益的方法.
该模型有效地阐明了测试物质的毒性作用的潜在机制.

结论:

REAM是对 PFAS 等新出现的污染物的初步评估的一个有价值的工具.
这种无细胞系统为加速毒理学研究和环境监测提供了一个有希望的策略.

关键词:

抗氧化剂防御的抗氧化剂防御催化酶是一种催化剂.细胞代谢的细胞代谢.谷氨酸减少酶的作用乳酸脱酶的使用方法皮鲁酸盐脱酶的使用方法

更多相关视频

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox

Published on: August 28, 2019

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

相关概念视频

Autoxidation of Ethers to Peroxides and Hydroperoxides

Autoxidation of Ethers to Peroxides and Hydroperoxides

Ethers represent a class of chemical compounds that become more dangerous with prolonged storage because they tend to form explosive peroxides when standing in the air. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly oxidize to form hydroperoxides and dialkyl peroxides.

Microbial Bioremediation of Pesticides

Microbial Bioremediation of Pesticides

Pesticides often feature structurally complex chemical architectures, incorporating halogen groups and multiple aromatic rings. These characteristics confer high chemical stability, rendering many pesticides resistant to natural degradation processes. This resistance poses significant environmental concerns, as persistent pesticide residues can accumulate in ecosystems and affect non-target organisms.Despite the inherent stability of many pesticides, certain microorganisms possess the metabolic...

Microbial Bioremediation of Plastics

Microbial Bioremediation of Plastics

Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...