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探索海洋乳酸菌及其蛋白质以益生菌为基础的口腔癌治疗

Sankarapandian Vidya¹, Govindasamy Thiruneelakandan², Rajapandiyan Krishnamoorthy³

¹Department of Microbiology & Immunology, Kampala International University, Western campus, Ishaka, Uganda.

International journal of biological macromolecules

|October 28, 2023

概括

海洋益生菌显示出抗癌潜力. 乳酸菌种及其蛋白质有效控制了子的瘤形成,通过向关键酶来延长寿命并抑制癌症生长.

科学领域:

海洋微生物学海洋微生物学
癌症生物学癌症生物学
益生菌研究的研究.

背景情况:

癌症仍然是导致死亡的主要原因,需要超越传统化疗的新型治疗策略.
益生菌越来越多地被认为具有潜在的健康益处,包括在疾病预防和治疗中的作用.
海洋环境拥有独特的微生物资源,具有潜在的生物技术应用.

研究的目的:

研究海洋乳酸菌种及其蛋白质的抗癌作用.
为了识别具有瘤抑制性质的特定海洋乳酸菌株.
阐明这些益生菌抗癌活性背后的分子机制.

主要方法:

从泰米尔纳德邦红树林皮查瓦拉姆 (TLMP) 森林中分离和识别了五种海洋乳酸菌种.
将乳酸菌分离物及其蛋白质给雄性金色叙利亚仓鼠.
瘤形成评估,寿命分析和分子对接研究.

主要成果:

海洋乳杆菌分离物及其蛋白质显著控制了子的瘤形成.
用乳酸菌治疗延长了瘤携带的仓鼠的寿命.
分子对接揭示了乳酸菌蛋白和cAMP依赖的蛋白激酶催化子单元α之间显著的相互作用,这对于瘤抑制至关重要.

结论:

海洋乳酸菌种及其蛋白质具有显著的抗癌特性.
这些益生菌为开发新型癌症疗法提供了有希望的途径.
抗癌机制涉及通过特定蛋白质相互作用抑制cAMP依赖的蛋白激酶.

关键词:

在这种情况下,细菌素可以牛乳杆菌 (Lactobacillus) 是一种细菌.口腔癌是一种口腔癌.益生菌益生菌益生菌蛋白质激酶酶是一种蛋白质激酶.

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