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鼻子对高温和大西洋鱼 (Gadus morhua) 的Francisella noatunensis感染的反应

Carlo C Lazado¹, Marianne Iversen², Lill-Heidi Johansen²

¹Nofima, The Norwegian Institute of Food, Fisheries and Aquaculture Research, Ås 1431, Norway.

|October 28, 2023

概括

升高的温度可以改变嗅觉器官.

科学领域:

水生动物的健康状况.
鱼类免疫学鱼类免疫学
分子生物学分子生物学

背景情况:

弗朗西塞拉诺阿图南斯 (Francisella noatunensis) 引起法兰西菌病,这是大西洋鱼的一个重要疾病.
了解鱼类中的宿主-病原体相互作用对于水产养殖至关重要.
温度是影响鱼类生理学和疾病易感性的关键环境因素.

研究的目的:

研究大西洋鱼嗅觉器官的组织学和转录学变化,这些鱼在实验中感染了Francisella noatunensis.
评估水温升高 (17°C与12°C) 对宿主感染的鼻腔反应的影响.

主要方法:

大西洋鱼在12°C和17°C时经过实验感染了Francisella noatunensis.
对鼻腔组织进行了组织学分析.
转录组分析 (RNA测序) 用于识别基因表达变化.

主要成果:

受感染的鱼类表现出典型的法兰西菌病理.
鼻子形态表型参数在很大程度上不受温度或感染的影响,除了12°C的粘液细胞计数.
在17°C的鱼类中,随着时间的推移,更多的基因被改变了;然而,终结时的转录组与对照组相似. 感染群体之间的比较显示了754个差异表达基因 (DEGs),其中许多与信号传递和防御有关.

结论:

高温可以影响嗅觉器官对大西洋鱼中Francisella noatunensis感染的反应.
温度调节了宿主在鼻子组织中的分子防御机制.
这些发现强调了环境因素在塑造鱼类疾病结果中的作用.

关键词:

水产养殖是水产养殖的一种方式.气候变化气候变化气候变化弗朗西斯病毒感染.粘膜免疫力粘膜免疫力鼻腔免疫力鼻腔免疫力嗅觉器官是一种嗅觉器官.有关RNA测序的RNA测序

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