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快速而强大的脉冲化学交换和转移 (CEST) MRI 使用准稳定状态 (QUASS) 算法在3 T

Qiting Wu¹, Yulong Qi², Pengcheng Gong³

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China; Medical AI Lab, School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, Guangdong, China.

Magnetic resonance imaging

|October 28, 2023

概括

一个新的QUASS算法可以实现更快,更准确的脉冲化学交换和转移 (CEST) MRI. 这种方法克服了以前技术的局限性,改善了肌肉疾病的检测.

科学领域:

磁共振成像技术磁共振成像技术
生物医学工程生物医学工程
频谱学是一种光谱学.

背景情况:

化学交换和转移 (CEST) 对于成像可变质子至关重要,但对和持续时间 (Tsat) 和放松延迟 (Trec) 敏感.
由于临床扫描仪的硬件和特定的吸收率限制,现有的准稳定状态 (QUASS) 解决方案不适合脉冲CESTMRI.
准确的CEST测量对于诊断各种疾病,特别是肌肉疾病至关重要.

研究的目的:

开发和验证一个用于脉冲CESTMRI的QUASS算法.
评估算法在肌肉组织中的性能.
评估Tsat/Trec对CEST测量的影响,并与新的QUASS方法进行比较.

主要方法:

开发了一种QUASS算法,将近似的稳定状态脉冲CEST信号纳入非共振自旋锁模型.
在健康的志愿者身上使用数值模拟,肌酸幻影和3T核磁共振扫描进行实验.
使用不对称性分析和单独的特定CEST贡献 (肌,APT,PCr,MT/NOE) 的量化CEST效应,使用多池罗伦斯模型.

主要成果:

显而易见的CEST测量受到Tsat/Trec的显著影响,与QUASS CEST相比显示较小的值,特别是短Tsat/Trec.
该QUASS算法证明了其稳定性,减轻了Tsat/Trec的影响,并允许准确的CEST测量.
这项研究证实了QUASS算法的加速脉冲CESTMRI和提高准确性的能力.

结论:

拟议的QUASS算法显著提高了脉冲CESTMRI的准确性和效率.
这一进步使得即使在和放松时间短,CEST测量也可以进行强大测量.
夸斯算法有望加速肌肉疾病的临床评估.

关键词:

化学交换和转移化学交换和转移脉冲式胸部脉冲式胸部脉冲式胸部几乎稳定的状态 (QUASS)

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