微生物依赖不成熟的髓状细胞的招募促进了肠道再生
Zhengyu Jiang1, Quin T Waterbury2, Ermanno Malagola1
1Division of Digestive and Liver Diseases Medicine, Irving Cancer Research Center, Department of Medicine, Columbia University Medical Center, New York, New York; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Cellular and molecular gastroenterology and hepatology
|October 28, 2023
概括
表达西丁脱酶 (Hdc) 的不成熟髓状细胞 (IMC) 通过与淋巴内皮细胞 (LEC) 相互作用,促进损伤后的肠道再生. 肠道微生物对于招募这些IMCs至关重要,突出了它们在粘膜修复中的作用.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 再生医学是一种再生医学.
背景情况:
- 肠上皮对于营养吸收和屏障功能至关重要.
- 淋巴内皮细胞 (LEC) 和不成熟的髓状细胞 (IMC) 参与肠道修复.
- 研究了表达histidine脱碳酶 (Hdc) 的IMCs在肠道再生中的作用.
研究的目的:
- 研究Hdc表达IMC在辐射损伤后肠道再生中的作用.
- 阐明IMCs对上皮细胞修复有所贡献的机制.
- 为了确定肠道微生物群对通过IMCs介导的肠道再生的影响.
主要方法:
- 使用西丁脱碳酶 (Hdc) 记者小鼠在照射后跟踪Hdc+ IMC.
- 采用Hdc+细胞的基因切除和Hdc+细胞中Ptgs2的条件淘汰.
- 评估了淋巴内皮细胞 (LEC) 活动和肠道微生物群枯竭的影响.
主要成果:
- Hdc+ IMCs透到受伤的肠道,通过调节LEC活性来促进上皮细胞的再生.
- Hdc+ IMCs通过Ptgs2产生前列腺素E2 (PGE2),该前列腺素通过Ptgs2对LECs起作用,以增强淋巴血管生成和前再生因子表达.
- 肠道微生物群的枯竭损害了IMC的招募,并减少了肠道再生.
结论:
- 通过调节LEC功能,Hdc+ IMCs在肠道修复中发挥着至关重要的作用.
- 肠道微生物是通过IMC招募肠道再生的重要媒介.
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