在精神病患者中,CYP1A2表达而不是基因型与奥兰zapine度有关
Ferenc Fekete1,2, Ádám Menus3, Katalin Tóth1
1Institute of Enzymology, HUN-REN Research Centre for Natural Sciences, Magyar tudósok 2, Budapest, 1117, Hungary.
Scientific reports
|October 29, 2023
概括
奥兰扎血度主要受到CYP1A2酶表达的影响,而不是遗传. 吸烟显著影响 olanzapine 水平,这表明 CYP1A2 mRNA 测量可以优化患者的剂量.
科学领域:
- 药物遗传学 药物遗传学
- 临床药理学 临床药理学
- 生物化学 生化学
背景情况:
- 奥兰沙平是一种非典型的抗精神病药物,由CYP1A2和CYP2D6酶代谢.
- 这些酶的遗传变异可能会影响药物度.
- 像吸烟这样的非遗传因素也会影响药物代谢.
研究的目的:
- 为了研究CYP1A2和CYP2D6遗传多态化对奥兰扎血度的影响.
- 评估非遗传因素对 CYP1A2 介导的 olanzapine 代谢的影响.
- 为了确定CYP1A2表达水平是否与患者的奥兰zapine暴露相关.
主要方法:
- 在139名精神病患者中,对CYP1A2和CYP2D6多态的基因定型.
- 对 olanzapine 血度的分析.
- 遗传数据和非遗传因素 (性别,年龄,吸烟) 与奥兰扎水平的相关性.
- 在白细胞中测量CYP1A2mRNA表达.
主要成果:
- CYP2D6基因型对 olanzapine 代谢的影响很小.
- 而CYP1A2表达,而不是遗传变异性,与奥兰zapine度有显著的关联.
- 吸烟增加了CYP1A2的mRNA表达,并影响了 olanzapine 的水平.
- 白细胞中的CYP1A2mRNA水平与患者的奥兰扎暴露相关.
结论:
- CYP1A2酶表达是患者对 olanzapine 暴露的主要决定因素.
- 吸烟通过CYP1A2诱导显著影响奥兰扎宾水平.
- 在白细胞中测量CYP1A2mRNA可能有助于个性化 olanzapine 剂量.
更多相关视频
12:00Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
13.0K
08:37Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods
Published on: June 25, 2019
8.1K
相关概念视频
01:26Psychosis: Goals of Pharmacotherapy
145
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
145
01:21Antipsychotic Drugs: Typical and Atypical Agents
223
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
223
01:23Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
167
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
167
01:28Psychosis and Antipsychotic Drugs: Overview
290
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
290
01:20Antiepileptic Drugs: Potassium Channel Activators
192
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
192
01:24Mania and Antimanic Drugs: Overview
203
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
203