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侧面的下丘脑前脑神经元驱动威胁诱导的过度饮食,与负面的情绪状态相关
In-Jee You1,2, Yeeun Bae1,2,3, Alec R Beck1,2
1Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA.
Nature communications
|October 29, 2023
概括
捕食者威胁使特定的大脑神经元对过度摄入高脂肪饮食敏感,导致情绪性饮食. 沉默这些神经元或阻断压力激素会使这种食行为正常化,揭示了压力诱导过度消费的关键大脑电路.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 行为科学 行为科学
背景情况:
- 心理压力因素会引发生理变化,影响食欲.
- 受到威胁诱导的养变化影响的下丘脑中的特定神经回路尚不清楚.
研究的目的:
- 为了研究捕食者嗅觉刺激 (PSS) 如何改变与食相关的下丘脑电路功能.
- 确定前脑素 (Penk) 表达的横向下丘脑神经元在威胁诱导的过度消费中的作用.
主要方法:
- 使用过的小鼠暴露在捕食者嗅觉刺激 (PSS) 中.
- 检查了侧面下丘脑Penk表达神经元 (LHPenk) 的功能,以应对高脂肪饮食 (HFD).
- 研究了脑下垂体中脑素,皮质和葡萄糖皮质受体 (GR) 的作用.
主要成果:
- PSS暴露使LHPenk神经元对HFD敏感,导致过度消费和负面情绪状态.
- 沉默LHPenk神经元使PSS诱导的HFD过度消费正常化.
- 在横向下丘脑 (LH) 中低调脑类对于抑制这些变化至关重要.
- 升高的皮质激素增强了含GR的LHPenk神经元对HFD的反应性.
- 在LH中抑制GR抑制了PSS诱导的适应不良行为.
结论:
- LHPenk神经元在威胁诱导的神经元适应过程中至关重要,导致情绪过度消费.
- 这项研究确定了一种神经机制,它将压力,食欲和情绪性饮食联系在一起.
- 针对LH中的GR可能为与压力相关的饮食障碍提供治疗策略.
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