从NAFLD到MAFLD的流行率和系统性炎症水平的转变:基于人口的横截面研究
Qingdan Liu1, Meilan Han2, Meilan Li3
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, University Town, No 1, Xue Yuan Road, Fuzhou, 350108, Fujian, China.
Lipids in health and disease
|October 29, 2023
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 更为普遍,并且显示出比非酒精性脂肪肝疾病 (NAFLD) 更高的系统性炎症. 系统性炎症指标对于诊断MAFLD或NAFLD都不有效.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 很少有研究比较了非酒精性脂肪肝病 (NAFLD) 和代谢功能障碍相关的脂肪肝病 (MAFLD) 的患病率和系统性炎症 (SI) 状态.
- MAFLD是一种新定义的疾病,可能比NAFLD更多的病例.
- 了解这些差异对于疾病管理和公共卫生战略至关重要.
研究的目的:
- 在中国东南地区的普通人口中比较MAFLD和NAFLD的流行率和系统性炎症水平.
- 探索疾病定义从NAFLD转变为MAFLD的影响.
- 评估SI指标在诊断这些疾病中的有用性.
主要方法:
- 分析了一组6718名一般人口参与者,年龄在35-75岁之间.
- 使用后勤回归和限制立方线 (RCS) 模型来评估15个SI指标与MAFLD/NAFLD之间的关联.
- 进行了接收器操作特征 (ROC) 曲线分析,以评估诊断准确性.
主要成果:
- MAFLD (34.7%) 的患病率高于NAFLD (32.4%),并有显著的重叠 (89.7%).
- 与只有NAFLD和非FLD组相比,仅MAFLD组的8个SI指标水平更高.
- 虽然10个SI指标是显著的预测指标,但ROC分析表明MAFLD和NAFLD的诊断准确性低 (AUC<0.7).
结论:
- MAFLD定义可能包括比NAFLD更多的脂肪肝患者.
- 只有MAFLD的组与仅NAFLD的组相比,呈现出更严重的炎症状态.
- 由于AUC和灵敏度较低,SI指标作为MAFLD或NAFLD的独立诊断工具具有有限的价值.
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