在患有症综合征的儿童中维生素D状态
Olena Riga1, Maxym Khaustov1, Aleksandra Mikhaylova1
1KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.
概括
患有麻综合征的儿童患维生素D缺乏症的患病率明显高,与健康儿童相比,这种病例的患病率是健康儿童的2.25倍. 这种缺陷在严重营养不良患者中尤为明显,这强调了针对性干预的必要性.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 神经学 神经学
背景情况:
- 患有麻综合征的儿童经常表现出影响其营养状况和维生素水平的并发症.
- 维生素D对骨健康和免疫功能至关重要,而维生素D的缺乏在儿童群体中越来越令人担忧.
研究的目的:
- 为了确定患有麻综合征的儿童的血清25...OH) D水平.
- 根据年龄,性别,抗使用和营养状况分析维生素D水平的分布.
- 为了比较患有麻综合征和没有麻综合征的儿童之间的维生素D状态.
主要方法:
- 一组77名患有麻综合征的儿童和73名健康儿童 (年龄在1-18岁) 在一年内 (秋季-春季) 进行了研究.
- 数据收集包括病史审查,医疗文件分析,使用总运动功能分类系统 (GMFCS) 评估运动功能障碍,以及营养状况评估.
- 测量和分析了与各种人口统计和临床因素相关的血清25(OH) D水平.
主要成果:
- 患有综合征的儿童的血清25(OH) D中位数为14.8 ng/mL,而健康儿童的血清25 ((OH) D中位数为18.3 ng/mL (p=0.0103).
- 维生素D缺乏症 (21-29 ng/mL) 在28.7%的受影响儿童中被观察到,而对照组为16.8%,而缺乏症 (<20 ng/mL) 在56.1%和72.2%.
- 严重的维生素D缺乏 (<10 ng/mL) 在麻综合征的儿童 (25.9% vs 10.9%,p=0.00189) 中显着更高,特别是那些营养不良的儿童.
结论:
- 维生素D缺乏在患有麻综合征的儿童中明显更为普遍 (2.25倍),特别是那些严重营养不良的儿童.
- 根据性别,GMFCS水平或抗药的使用,没有发现25...OH) D水平的显著差异.
- 需要进一步的研究,以探索这种脆弱的儿科群体中维生素D缺乏的具体干预措施.
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