在血液中风的建模下,大鼠大脑的传感运动皮质的变化
Tetiana M Oliinyk1, Liudmyla M Sokurenko2, Rostyslav F Kaminsky2
1NATIONAL UNIVERSITY OF UKRAINE ON PHYSICAL EDUCATION AND SPORT, KYIV, UKRAINE.
Wiadomosci lekarskie (Warsaw, Poland : 1960)
|October 29, 2023
概括
在老鼠中,出血性中风导致大脑胀,线粒体胀和脂质过氧化增加. 抗氧化酶活性下降,导致细胞通过亡和亡死亡.
科学领域:
- 神经科学是一个神经科学.
- 病理学 病理学 病理学
- 生物化学 生物化学
背景情况:
- 流血性中风是一种严重的神经疾病.
- 了解它对大脑组织的影响对于开发治疗方法至关重要.
研究的目的:
- 在诱导出血性中风后,研究大鼠感觉运动皮质的结构和代谢变化.
主要方法:
- 在老鼠中出血性中风模型.
- 组织学和电子显微镜.
- 生物化学试验和生物标记物.
主要成果:
- 在受影响半球中观察到脑 edem 和神经退行.
- 线粒体胀和激活脂质过氧化.
- 降低了抗氧化酶活性,降低了亡标志物,并抑制了ERK1/2表达.
- 在皮层细胞中存在亡和亡的证据.
结论:
- 流血性中风会引起,细胞死亡 (和亡) 和氧化应激.
- 减少抗氧化剂防御机制与中风病理有关.
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