甲状腺激素失衡和结直肠癌的风险:一个元分析
Omid Asbaghi1, Ghazaleh Shimi2, Sayed Hossein Davoodi1,3
1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of gastrointestinal cancer
|October 29, 2023
概括
这次元分析发现甲状腺疾病 (如甲状腺功能低下症或甲状腺功能过高症) 与结直肠癌 (CRC) 风险之间没有显著联系. 对于特定的区域或小样本人口的发现,需要进一步的研究.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 甲状腺功能障碍,包括甲状腺功能低下和甲状腺功能过高,是常见的.
- 甲状腺疾病与结直肠癌 (CRC) 风险之间的关系尚不清楚.
- 观察性研究对这种关联产生了不一致的结果.
研究的目的:
- 系统地审查和元分析观察性研究,调查甲状腺功能低下症或甲状腺功能增强症与CRC风险之间的关联.
- 提供关于甲状腺功能和结直肠癌发病率的当前证据的全面摘要.
主要方法:
- 在主要的在线数据库中进行了全面的文献搜索,截至2023年7月.
- 使用随机效应模型计算聚合效应大小 (ESs) 和95%置信区间 (CI).
- 在分析中包括了13项相关研究,包括33557450名个人和25363例CRC病例.
主要成果:
- 整体元分析显示,甲状腺功能低下症和CRC风险之间没有统计学上显著的关联 (ES:1.13,95% CI:0.87-1.48,P=0.343).
- 同样,甲状腺功能过高和CRC风险之间也没有发现显著的关联 (ES:1.09,95% CI:0.75-1.57,P=0.638).
- 然而,在远东研究的甲状腺功能低下症和中东研究的甲状腺功能过高症的子组分析中,以及在样本小的研究中观察到显著的关联.
结论:
- 这一元分析得出的结论是,甲状腺功能低下症或甲状腺功能增强症与患结直肠癌的风险之间没有总体显著的关联.
- 在特定区域或小样本研究中观察到的关联需要进一步调查,以澄清潜在的混因素或特定的人口风险.
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