老年人的休息心率,认知功能和炎症:基于人口的研究
Ming Mao1, Rui Liu1, Yi Dong2,3
1Department of Neurology, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, No. 324 Jingwuweiqi Road, Jinan, 250021, Shandong, People's Republic of China.
Aging clinical and experimental research
|October 29, 2023
概括
休息心率 (RHR) 的升高与老年人的认知功能较差有关. 这种关联可能涉及全身炎症和内皮损伤,这表明认知能力下降的潜在机制.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
背景情况:
- 越来越多的证据表明,在老年人中,心率 (RHR) 升高和认知功能下降之间存在联系.
- 连接RHR和认知衰退的潜在生物机制在很大程度上仍未被探索.
研究的目的:
- 在一大群老年人中调查休息心率 (RHR) 和认知功能之间的关联.
- 探索系统性炎症和内皮标记在这种关系中的潜在调解作用.
主要方法:
- 这是一项以人口为基础,对4510名65岁及以上无痴呆症的参与者进行的横截面研究.
- 使用迷你精神状态检查 (MMSE) 和神经心理测试电池评估认知功能.
- 通过心电图测量休息心率 (RHR);在子样本中分析血清生物标志物.
主要成果:
- 较高的RHR与较差的认知功能 (MMSE和注意力得分) 和心脏代谢疾病的患病率增加有关.
- 在RHR和认知得分之间观察到一个反转的J形关联.
- RHR显示与高水平的促炎细胞因子 (IL-6,IL-8,IL-10,TNF-α) 和粘附分子 (MCP-1,ICAM-1,VCAM-1) 的线性关联.
结论:
- 在RHR和认知功能之间存在一个反转的J形关系,特别是注意力和全球认知.
- 系统性低度炎症和内皮损伤是将高RHR与老年人认知功能低下联系起来的潜在机制.
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