急性缺氧会损害大脑后部的生物能量和人类的记忆力
Soichi Ando1, Hayato Tsukamoto2,3, Benjamin S Stacey2
1Graduate School of Informatics and Engineering, The University of Electro-Communications, Tokyo, Japan.
Experimental physiology
|October 29, 2023
概括
急性缺氧会损害记忆功能,同时保持注意力和反应抑制等执行功能. 这种选择性脆弱性与减少向大脑后动脉输送氧气有关.
科学领域:
- 神经科学是一个神经科学.
- 人体生理学 人体生理学
- 认知科学 认知科学
背景情况:
- 缺氧或低氧水平可能会损害认知功能,但具体受影响的认知领域仍然不清楚.
- 了解这些影响对于管理涉及氧气供应减少的情况至关重要.
研究的目的:
- 研究急性缺氧对中央执行功能 (选择性注意力,响应抑制) 和非执行功能 (记忆) 的影响.
- 确定认知障碍是否与区域大脑血流和氧气输送有关 (CDO2).
主要方法:
- 十二名男性参与者在随机的,单盲交叉设计中暴露于多达6小时的正常氧和缺氧 (12%O2) 中.
- 认知任务 (去/不去,记忆) 在不同的时间点执行.
- 在中脑动脉 (MCA) 和后脑动脉 (PCA) 中测量大脑血流速度,使用跨的多普勒超声波来评估CDO2.
主要成果:
- 在缺氧下,记忆任务的准确性显著下降 (P=0.049).
- 氧气输送 (DO2) 到后脑动脉 (PCA) 在记忆编码和回忆中减少,而缺氧 (P=0.005,P=0.002).
- 中央执行功能,包括反应时间和Go/No-Go任务的准确性,没有受到缺氧的影响 (P>0.19).
结论:
- 记忆功能选择性地容易受到急性缺氧的影响.
- 减少向PCA的氧气输送可能是缺氧期间记忆障碍的基础.
- 执行功能,如选择性注意力和响应抑制,对急性缺氧条件具有弹性.
相关概念视频
01:23Hypoxia
1.1K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.1K
01:26Higher Mental Functions of Brain: Learning and Memory
837
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
837
01:21Acute Respiratory Failure-II
249
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
249