帕金森病和牙周炎之间是否存在关联? 一个系统的审查和元分析
Yiqun Chen1, Yining Jin2, Kun Li1
1The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, China.
Journal of Parkinson's disease
|October 29, 2023
概括
这项研究发现帕金森病 (PD) 和牙周炎风险之间没有显著联系. 然而,PD患者的牙周炎患病率较高,口腔健康指标较差.
科学领域:
- 神经学 神经学
- 牙周病学 牙周病学
- 流行病学 流行病学
背景情况:
- 关于帕金森病 (PD) 和牙周炎之间的关联存在相互矛盾的结果.
- 观察性研究对这种潜在联系产生了有争议的发现.
研究的目的:
- 系统地审查和元分析帕金森病和牙周炎之间的双向关系.
- 为了澄清PD与牙周炎风险之间的关联.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Cochrane Library,Web of Science) 进行了全面的文献搜索,截至2022年12月19日.
- 使用随机效应模型进行系统审查和元分析,包括敏感性分析.
- 孟德尔的随机化被用来评估因果关系.
主要成果:
- 对34项研究的元分析 (24项用于定量分析) 显示牙周炎和PD风险之间没有显著的关联 (HR=1.13,OR=1.94).
- 门德尔随机化证实PD与牙周炎风险之间没有因果关系 (B=-0.0001,p=0.19).
- 患有PD的患者表现出明显更高的牙周口袋深度,临床附着水平,斑块指数和较差的口腔健康影响概况-14分数.
结论:
- 没有证据支持帕金森病风险和牙周炎风险之间的双向关联.
- 尽管缺乏因果关系,PD患者患有更高的牙周炎和口腔健康状况受损.
相关概念视频
Parkinson's Disease: Overview
567
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
567
Parkinson's Disease: Treatment
281
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
281
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K


