[卵泡淋巴瘤的治疗策略]
1Department of Hematology, Tohoku University Hospital.
[Rinsho ketsueki] The Japanese journal of clinical hematology
|October 29, 2023
概括
毛囊性淋巴瘤 (FL) 是一种惰性淋巴瘤,通常是无法治愈的. 目前的策略包括警等待,化疗和新兴疗法,如耐火病例的CAR T细胞疗法.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 毛囊性淋巴瘤 (FL) 是最常见的惰性非霍奇金淋巴瘤.
- 虽然抗CD20抗体治疗改善了结果,但FL对于大多数患者来说仍然无法治愈.
- 目前的管理包括对低瘤负担的警等待和对高瘤负担的化疗免疫治疗.
研究的目的:
- 审查毛囊淋巴瘤的当前治疗策略.
- 讨论FL管理中的关键预后因素.
- 为突出新兴的耐火性疾病治疗方法.
主要方法:
- 对当前毛囊淋巴瘤治疗指南和临床试验的文献综述.
- 对影响患者结果的预后因素的分析.
- 对新型治疗方法的评估.
主要成果:
- 警的等待是高级阶段,低瘤负担的FL的标准.
- 化疗免疫疗法跟随维护是高瘤负担FL的标准,尽管维护疗效仍有争议.
- 组织学转变是复发性FL的关键预后因素.
- 抗CD19CART细胞和CD20/CD3双特异性抗体对耐火性FL显示有希望.
结论:
- 毛囊淋巴瘤治疗正在发展,关于最佳Rituximab时间和维持治疗疗效的持续问题.
- 预后因素,特别是组织学转变,对于指导治疗决策至关重要.
- 新型免疫疗法为耐火性卵泡淋巴瘤患者提供了新的希望.
相关概念视频
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Tumor Immunotherapy
538
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
538
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
170
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
170
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Pulmonary Tuberculosis V
183
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
183


