[嗅觉癌的临床病理特征]
1Center of Clinical Pathology, the First Affiliated Hospital of University of Science and Technology of China/Anhui Provincial Hospital, University of Science and Technology of China, Hefei 230036, China.
Zhonghua bing li xue za zhi = Chinese journal of pathology
|October 29, 2023
概括
嗅觉癌 (OC) 是一种罕见的鼻瘤. 其多样化的组织形态学和免疫组织化学特征是准确诊断的关键,并将其与嗅觉神经母细胞瘤 (ONB) 区分开来.
科学领域:
- 病理学 病理学 病理学
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 嗅觉癌 (OC) 是一种罕见的恶性瘤,发生在鼻道.
- 区分OC与其他鼻腔瘤,特别是嗅觉神经母细胞瘤 (ONB),由于重叠的特征,可能具有挑战性.
- 了解OC的临床病理特征对于准确的诊断和患者管理至关重要.
研究的目的:
- 研究嗅觉癌 (OC) 的临床病理特征.
- 探索OC的差异诊断,特别是与嗅觉神经母细胞瘤 (ONB) 的关系.
- 突出免疫组织化学在诊断OC中的作用.
主要方法:
- 对2016年1月至2022年8月期间诊断的21例鼻瘤病例的回顾性审查.
- 根据详细的基因病理学和免疫组织化学分析,将3个病例重新归类为OC.
- 将OC病例与18例对照病例 (最初被诊断为ONB或不确定的诊断) 的比较.
主要成果:
- 确定了三起OC病例 (2名男性,1名女性;平均年龄57岁).
- 显微镜的发现揭示了多种不同的模式,包括固体巢,花束,伪花束和异常腺体.
- 免疫组织化学显示了表皮和神经内分泌标记物的扩散表达,瘤细胞中的p40/p63阳性和支柱细胞中的S-100. 像NUT,CD99和desmin这样的标记物是负的. 基-67指数在20%至80%之间.
结论:
- 嗅觉癌是一种罕见的鼻瘤,具有神经上皮细胞分化.
- 它的组织形态非常可变,需要全面的诊断方法.
- 免疫组织化学标记物的组合对于准确诊断和OC的区分至关重要.
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