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在不同的牙周条件下对临时定装置上的口腔微生物组的分析

Ningrui Zhao^1,2, Qian Zhang³, Yanning Guo^1,2

¹Department of Orthodontics, Peking University School and Hospital of Stomatology, 22# Zhongguancun South Avenue, Beijing, 100081, China.

Progress in orthodontics

|October 30, 2023

概括

牙周炎显著改变了正临时定装置 (TAD) 上的口腔微生物组. 与牙周健康个体相比,患有牙周炎的患者在TAD表面上表现出明显的微生物殖民和功能特征.

科学领域:

矯正牙科矯正牙科是一種矯正牙科.
微生物学微生物学
牙周病学牙周病学

背景情况:

临时固定装置 (TAD) 在正牙治疗中至关重要.
了解TADs上的微生物殖民对于患者健康至关重要.
牙周炎对TAD微生物群的影响尚未完全理解.

研究的目的:

调查牙周炎病史对牙科TAD表面微生物组合和功能的影响.
为了比较牙周健康和牙周炎患者之间的微生物殖民模式.

主要方法:

根据牙周健康状况 (健康与牙周炎第二阶段或更严重) 进行患者分组.
扫描电子显微镜 (SEM) 用于生物膜可视化.
16S rRNA基因测序用于TADs的微生物分析.
多样性指数 (α和β) 和KEGG功能分析.

主要成果:

在两组中,SEM证实了TADs上的细菌殖民.
基于牙周状况的β-多样性分析显示出不同的微生物聚类 (P < 0.01).
在牙周炎组中,特定的属 (例如,Fusobacterium,Porphyromonas) 得到了丰富.
在牙周炎组中,KEGG分析显示了与代谢和遗传处理相关的微生物功能的改变.

结论:

牙周炎显著改变了正牙TADs上的口腔微生物组合和功能.
这些发现突出了牙周健康在TADs的正牙治疗管理中的重要性.
这项研究提供了与牙周炎患者TAD相关的微生物景观的见解.

关键词:

微生物组是一个微生物组.ортодонтическое 治疗 ортодонтическое 治疗牙周病是指牙周病的发生.临时安装装置的临时安装装置.

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