没有明显的Helicobacter pylori感染和结直肠癌之间的因果关系:一个双向的门德尔随机化研究
Fang Luo1, Peipei Zhou1, Xiong Ran2
1Department of Gastroenterology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China.
Scientific reports
|October 30, 2023
概括
这项研究使用遗传数据发现,Helicobacter pylori感染和结直肠癌 (CRC) 之间没有因果关系. 需要进一步的研究来了解H. pylori和CRC之间的相关性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 观察性研究表明,Helicobacter pylori感染和结肠直肠癌 (CRC) 之间存在相关性.
- 因果关系和潜在的机制仍然不清楚.
- 杆菌感染是胃癌的已知风险因素,促使对其在CRC中的作用进行调查.
研究的目的:
- 调查H. pylori感染和CRC之间的潜在因果关系.
- 评估H. pylori CagA和VacA抗体在CRC发展中的作用.
- 用遗传流行病学方法区分因果关系和因果关系.
主要方法:
- 孟德尔随机化 (MR) 研究利用两样本全基因组关联研究 (GWAS) 数据.
- 双向MR分析以评估两个方向的因果关系 (H. pylori到CRC和CRC到H. pylori).
- 采用了反向方差加权,加权中位数和MR-Egger回归技术,并使用MR-PRESSO进行异常值校正.
主要成果:
- 在基因预测的H. pylori血清阳性和CRC之间没有发现统计学上显著的因果关系 (OR:1.12,P=0.08).
- 杆菌VacA抗体水平 (OR=0.96,P=0.25) 和CagA抗体水平 (OR=1.00,P=0.92) 也显示没有与CRC的因果关系.
- 反向MR分析证实没有证据表明CRC导致H. pylori感染.
结论:
- 这项MR研究没有为H. pylori感染和结直肠癌之间的因果关系提供遗传证据.
- 在观察性研究中观察到的相关性可能是由于混因素或其他未测量的变量.
- 需要进一步的研究来阐明H. pylori和CRC病原体之间的复杂相互作用.
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