基于扩散张力成像的发育预测建模,揭示了幼儿期自闭症大脑中年龄依赖的异质性
Xinyue Huang1,2, Yating Ming1,2, Weixing Zhao1,2
1The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.
Molecular autism
|October 30, 2023
概括
自闭症白质微观结构在幼儿时代显示出不同的发育模式. 结果揭示了两个子组:一个具有过度生长和低自闭症特征,另一个具有延迟成熟和高特征.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 生物医学成像技术 生物医学成像技术
背景情况:
- 证据表明自闭症中异常白质 (WM) 微观结构,但研究结果不一致.
- 快速的早期儿童大脑发育可能导致自闭症研究的结果分歧.
- 了解WM微观结构的发展轨迹对于自闭症研究至关重要.
研究的目的:
- 调查幼儿时期自闭症儿童白质 (WM) 微观结构的发育性质.
- 考虑发育变异来划分非典型的WM微观结构模式.
- 根据WM发展,确定自闭症儿童的不同子组.
主要方法:
- 扩散张力成像 (DTI) 用于自闭症儿童和4-7岁典型发育儿童 (TDC) 的两个独立队列.
- 基于TDC数据的发育预测建模 (支持向量回归) 估计了自闭症儿童的WM非典型发育指数.
- K-means集群确定了子组,然后使用t测试进行比较,并对与年龄相关的关联进行部分相关性. 无值集群增强 (TFCE) 用于WM微结构组比较.
主要成果:
- 自闭症儿童被分为两个分组,分别具有不同的发育阶段和WM异常发育的年龄依赖变异.
- WM非典型发育指数显示与年龄有负相关性.
- 第1小组表现出过度生长模式,自闭症特征较少,而第2小组表现出延迟成熟,自闭症特征更明显.
结论:
- 早期儿童自闭症的特点是白质 (WM) 微观结构的年龄依赖异质性.
- 发现了两种不同的发育模式:过度生长模式和延迟成熟模式.
- 这些发现强调了在检查自闭症中WM微观结构时考虑发育阶段的重要性.
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