孕期血清雷丁醇缺乏与乳低成形有关
S R Samuel1, C W M Lai2, M M Khan3
1The Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada.
Journal of dental research
|October 30, 2023
概括
产前血清雷丁醇缺乏症显著增加了儿童的叶落牙的牙质缺血症 (EH) 的风险. 这一发现强调了母亲的维生素A状况对婴儿口腔健康的重要性.
科学领域:
- 儿科牙科 儿科牙科
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 乳缺血症 (EH) 是一种常见的发育缺陷,影响牙结构.
- 产前营养缺乏是已知的EHS风险因素.
- 在EH中产前视网醇缺乏的特定作用需要进一步调查.
研究的目的:
- 评估孕期早期母亲血清二醇缺乏与落叶牙中牙面膜缺血的风险之间的关联.
- 为了确定其他潜在的风险因素对后代的EH.
主要方法:
- 一项前性队列研究,涉及1450名孕妇.
- 评估孕期12-14周之间的母体血清视网醇和其他营养标志物.
- 半年对后代进行口腔检查以诊断EH,使用2年的修改后的DDE指数.
主要成果:
- 孕产妇的视网醇缺乏症显著增加了叶落性EH的风险 (RR,2.0;95% CI,1.1-3.7).
- 血清25-基维生素D (25OHD) 缺乏,剖腹产,特定的宗教信仰和非常早产也与增加的EH风险有关.
- 大切口是最常受到影响的牙.
结论:
- 怀孕早期母亲血清二醇缺乏是叶落性质低成形的重要危险因素.
- 这一发现进一步证实了25OHD缺陷在EH发育中的作用.
- 确保适当的母体维生素A状况可能对预防儿童质缺陷至关重要.
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