一本关于化学抗原受体T细胞治疗相关的毒性对密集主义者的入门书
Shin Yeu Ong1,2, John H Baird1
1Division of Lymphoma, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.
Journal of intensive care medicine
|October 30, 2023
概括
化学抗原受体 (CAR) T细胞疗法提供了显著的癌症治疗益处,但可能导致严重的毒性. 强化治疗师必须管理这些免疫介导的不良事件,包括细胞因子释放综合征 (CRS) 和神经毒性 (ICANS).
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 关键护理医学 关键护理医学
背景情况:
- 化学抗原受体 (CAR) T细胞疗法在血液恶性瘤中显示出高疗效.
- 卡尔T细胞疗法与严重的免疫中介毒性有关,需要密集护理.
- 密集治疗师需要专门的知识来管理CAR T细胞治疗不良事件.
研究的目的:
- 对CAR T细胞疗法毒性的诊断标准和治疗策略进行审查.
- 讨论细胞因子释放综合征 (CRS) 和神经毒性 (ICANS) 的管理.
- 概述细胞衰竭,免疫抑制和感染的支持性护理和预防方法.
主要方法:
- 对当前诊断标准的文献综述.
- 对减轻毒性治疗策略的分析.
- 支持性护理和预防建议的审查.
主要成果:
- 包括CRS和ICANS在内的CAR T细胞治疗毒性,在30%的患者中需要密集护理.
- 对CRS和ICANS的有效管理策略至关重要.
- 最好的支持性护理和预防对于其他毒性如细胞衰竭和感染至关重要.
结论:
- 临界护理专家对于接受CAR T细胞治疗的患者的管理至关重要.
- 随着CAR T细胞治疗的广泛采用,重症治疗师的作用正在扩大.
- 多学科团队合作是CAR T细胞疗法的成功的关键.
关键词:
通过CAR T细胞疗法进行治疗.在CART-T中,我们可以使用CAR-T.在CRS中,您可以使用CRS.在ICANS中,我们可以看到ICANS.仿制性抗原受体的仿制性抗原受体细胞因子释放综合征 细胞因子释放综合征细胞衰减症是什么感染的感染感染.神经毒性的作用.更多相关视频
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