在狗中与急性勒螺旋症相关的外出性球炎
Monika Hilbe1, Horst Posthaus2, Giulia Paternoster3
1Vetsuisse Faculty, Zurich, Switzerland.
Veterinary pathology
|October 30, 2023
概括
狗的急性勒托斯皮罗斯症可能会导致严重的损伤,特别是排泄性淋巴结膜炎 (GN). 这项研究证实了白螺旋体是瑞士犬中新发现的这种病理变化的常见原因.
科学领域:
- 兽医病理学 兽医病理学
- 狗的传染病 狗的传染病
背景情况:
- 在过去的二十年中,在瑞士,在疑似急性白球症的狗中越来越多地观察到严重的球变化,称为排泄性球炎 (GN).
- 这些变化,以红细胞扩散和纤维素排泄到尿路空间为特征,以前没有报告过.
研究的目的:
- 描述狗狗中排泄性GN的病理特征.
- 来自瑞士的狗病例中调查出汗性GN和白病之间的关联.
主要方法:
- 从瑞士病理档案馆回顾了50个具有排泄性GN的犬类组织样本.
- 通过使用H&E,PAS,PTAH和Wartthin-Starry染色剂进行组织病理学检查.
- 使用免疫组织化学 (IHC) 和PCR,包括新型抗体组合,对LeptoSpirosis进行确认测试.
主要成果:
- 在50例排泄性GN病例中,37例确诊为白螺旋症阳性.
- 通过双重抗体 (LipL32和OMV2177) 的使用,排泄性GN中*Leptospira*的增强IHC检测率从24%增加到62%.
- 排泄性GN的狗的临床和病理发现与LeptoSpirosis一致.
结论:
- 排泄性GN是瑞士犬患有白病的重大病理发现,导致严重的急性疾病.
- 在诊断狗的排泄性GN时,病理学家应该考虑LeptoSpirosis.
- 具体的致病机制和独特的地理血清病毒的潜在参与需要进一步调查.
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