表观遗传年龄加速和时间年龄:与日常生活中的认知表现的关联
Daisy V Zavala1, Natalie Dzikowski2, Shyamalika Gopalan3
1Department of Psychology, Stony Brook University, Stony Brook, New York, USA.
概括
表观遗传年龄加速,生物衰老的衡量标准,与较差的认知功能和处理速度和工作记忆的变化增加有关. 这一发现表明,表观遗传时钟可能比单独的时间年龄更深入地了解认知衰老.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 由DNA甲基化衍生出的表观遗传钟可以测量衰老加速.
- 年龄加速可能更好地解释认知衰老,而不是时间的年龄.
- 认知功能随着年龄的增长而下降,显示出显著的个体差异.
研究的目的:
- 研究中年成人五种表观遗传衰老加速措施与认知表现 (处理速度,工作记忆) 之间的关联.
- 为了确定表观遗传年龄加速是否预测认知性能水平和可变性.
- 为了比较表观遗传年龄加速与时间年龄对认知的影响.
主要方法:
- 利用了来自142个基因多样化的中年成人的门诊认知评估数据.
- 采用多层模型来分析五个表观遗传时钟 (Horvath 1,Horvath 2,Hannum,PhenoAge,GrimAge) 和认知措施之间的关联.
- 在分析中对时间表年龄进行控制.
主要成果:
- 阳性年龄加速 (表观遗传年龄> 年代年龄) 与较差的平均处理速度 (Horvath 1,2) 和工作记忆 (GrimAge) 相相关.
- 积极的年龄加速通常与处理速度和工作记忆的更大个体内变异性有关.
- 时间学年龄与较差的认知表现和较少的个体内变异性有关.
结论:
- 表观遗传年龄加速与认知表现和可变性有关,可能提供超越时间学年龄的见解.
- 年龄加速对认知的影响可能与时间年龄相比或更大.
- 表观遗传年龄加速可能代表认知衰退的额外危险因素,以及认知表现的个体间差异.
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