D3 - 肌酸稀释,计算机断层扫描和双能X射线吸收测量用于评估结肠癌中肌和身体功能:一个横截面研究
En Cheng1,2, Bette J Caan2, Peggy M Cawthon3,4
1Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Journal of cachexia, sarcopenia and muscle
|October 30, 2023
概括
这项研究表明,在结肠癌患者中评估低骨肌量 (肌) 的D3-肌稀释,CT CSA和DXA ALM方法产生不同的结果,特别是在女性中. 肌肉质量测量及其与身体功能的关联是特定于性别的.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 老年学是一门学科.
背景情况:
- 低骨肌量 (肌肉缺陷症) 在癌症患者中很普遍,影响功能和生存.
- 以前的瘤学研究使用了CT CSA或DXA ALM等替代品,而不是总体肌肉质量.
- D3-肌酸 (D3Cr) 稀释提供了一种非侵入性方法来评估全身骨肌肉质量,此前未在癌症群体中进行评估.
研究的目的:
- 为了比较D3Cr肌肉质量,CT CSA和DXA ALM与结肠癌患者的肌和身体功能之间的关联.
- 评估这些关联中的性别特异性差异.
主要方法:
- 一项涉及119名结肠癌患者 (2018-2022) 的横截面研究.
- 肌盲症被定义为D3Cr,CT CSA和DXA ALM的最低性别特定四分位数.
- 使用短物理性能电池和握力强度评估的身体功能.
- 计算了性别特定的皮尔森相关系数和科恩的卡帕系数.
主要成果:
- 在男性中,D3Cr,CT和DXA之间的相关性和肌肉衰竭协议比女性更强.
- 在男性中,较高的D3Cr肌肉质量与步行速度和握力有显著的相关性.
- 在女性中,肌肉/瘦身量测量和身体功能之间没有显著的关联.
结论:
- 这是第一个使用D3-肌酸稀释用于癌症患者肌肉质量评估的研究.
- D3Cr,CT和DXA在肌和身体功能评估中是不可互换的,特别是在患有结肠癌的女性中.
- 未来的研究应该在不同类型的癌症中探索D3Cr,并考虑技术特定的优势.
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