机器人芯片:当前的挑战,趋势和未来的医疗领域
Zhangjie Li1, Qinyu Li2, Chenyang Zhou1
1Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Biomicrofluidics
|October 30, 2023
概括
芯片上的器官,模仿器官的3D模型,先进的药物查和精准医学. 本综述探讨了它们在生物医学中的好处,挑战和未来潜力.
科学领域:
- 生物医学工程 生物医学工程
- 组织工程是组织工程.
- 微流体学 微流体学
背景情况:
- 体外有机体模型是3D多细胞聚合物,用于药物查,疾病研究和精密医学.
- 芯片上的有机体技术将有机体与微流体相结合,以创建仿生生理微环境.
- 这项技术能够精确调节诸如流体流动和生化梯度等参数,模仿体内条件.
研究的目的:
- 介绍有机体在芯片系统的优点和特点.
- 讨论有关有机体培养,细胞外矩阵开发和设备制造的当前挑战.
- 探索有机体在芯片技术的潜在替代方法和未来方向.
主要方法:
- 这是一个视角审查,分析现有的文献和技术.
- 它讨论了先进的微流体与有机体模型的整合.
- 该审查审查了微纳米设备和组织结构的制造技术.
主要成果:
- 芯片上的器官系统提供了一个灵活的平台来复制体内器官功能.
- 关键的挑战包括优化有机体培养,细胞外矩阵支架和设备制造.
- 突出了潜在的替代方法和创新方法.
结论:
- 使用芯片上的有机体进行工程器官重建,代表了生物医学中的新范式.
- 在微纳米制造和组织工程方面需要进一步的创新.
- 该技术对未来的制药开发和临床应用具有重大前景.
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