在中国人口中,WTAP基因变异和对卵巢内膜异位症的易感性
Zixian Wan1,2, Lu Ye3, Guange Chen4
1Research Institute for Maternal and Child Health, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China.
Frontiers in genetics
|October 30, 2023
概括
威尔姆斯瘤1-关联蛋白 (WTAP) 基因中的遗传变异与子宫内膜异位症风险有关. 特定的WTAP单核酸多态 (SNP) 增加了易感性,特别是在年轻的中国女性中.
科学领域:
- 遗传学 遗传学 是一个
- 妇科 妇科 妇科 妇科
- 分子生物学分子生物学
背景情况:
- 子宫内膜异位症是一种普遍的妇科疾病,严重影响妇女的健康.
- 威尔姆斯瘤1-关联蛋白 (WTAP) 对于RNA甲基化至关重要,并与各种疾病有关.
- 在子宫内膜异位症风险中,WTAP基因单核酸多态 (SNP) 的作用尚未被探索.
研究的目的:
- 调查WTAP基因多态化与卵巢内膜异位症风险之间的关联.
- 识别可能使个体易患子宫内膜异位症的特定WTAPSNP.
主要方法:
- 在473名子宫内膜异位症患者和459名使用MassArray iPLEX的对照组中,对三种WTAP多态的基因定型.
- 后勤回归模型来分析WTAP SNPs与子宫内膜异位症风险之间的关联.
- 分层和单元型分析以进一步探索风险关联和可靠性.
主要成果:
- 在 rs1853259 G 变异和 rs7766006 T 变异基因型中,与改变子宫内膜异位症风险有显著的关联.
- 具有两种不利基因型的个体的风险明显更高 (调整后OR=1.71).
- 特定的基因型 (rs1853259 AG/GG,rs7766006 GG) 在某些亚组中增加了风险,并且哈普洛型分析显示,GGG哈普洛型的风险更高.
结论:
- WTAP基因多态性与中国妇女对卵巢内膜异位症的易感性有关.
- 这些发现突出了WTAP作为影响子宫内膜异位症发展的潜在遗传因素.
- 进一步的研究可以探索WTAP在子宫内膜异位症发病过程中的功能作用.
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