在甲状腺结节手术中,血清甲状腺蛋白,甲状腺刺激激素水平和甲状腺癌风险的相关性分析
Jin-Hao Shuai1, Zhao-Fang Leng2, Peng Wang2
1Department of Thyroid and Breast Surgery, Meishan City People's Hospital, Meishan 620000, Sichuan Province, China. jinhaoshuai236@163.com.
World journal of clinical cases
|October 30, 2023
概括
血清甲状腺蛋白 (Tg) 水平与患有甲状腺结节的患者甲状腺癌风险增加有关. 甲状腺刺激激素 (TSH) 水平没有显著的关联. 这些发现突出了Tg作为甲状腺癌风险评估的潜在生物标志物.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 甲状腺蛋白 (Tg) 是甲状腺癌的已知标记物,高水平通常在恶性瘤中见到.
- 甲状腺刺激激素 (TSH) 影响甲状腺功能,异常水平可能与甲状腺癌风险相关.
- 了解Tg,TSH和甲状腺癌之间的关系对于准确的诊断和治疗至关重要.
研究的目的:
- 研究血清甲状腺蛋白 (Tg) 和甲状腺刺激激素 (TSH) 水平与甲状腺癌风险之间的关联.
- 为了确定Tg和TSH水平是否可以预测患有甲状腺结节的患者的恶性瘤.
主要方法:
- 对130名接受甲状腺结节手术的患者的临床数据和实验室结果的回顾性分析.
- 在手术前记录血清Tg和TSH水平.
- 相关性分析以评估Tg/TSH水平与通过组织病理学确认的甲状腺癌诊断之间的关联.
主要成果:
- 在血清Tg水平和甲状腺癌风险之间发现了显著的正相关性 (P <0.05).
- 高血清Tg水平与甲状腺癌的风险增加有关.
- 血清TSH水平和甲状腺癌风险之间没有明显的相关性 (P > 0.05).
结论:
- 在接受甲状腺结节手术的患者中,血清Tg水平与甲状腺癌风险有显著的相关性.
- 在这一组患者中,血清TSH水平与甲状腺癌风险没有显著的相关性.
- 血清Tg可以被认为是评估甲状腺癌风险的重要生物标志物.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
The Thyroid Gland
3.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.9K
Serum Laboratory Studies, Stool Test, Breath Test
356
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
356


