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Updated: Jul 12, 2025

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
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独立于P53的致病机制有助于BubR1小头症

Noelle A Sterling1,2, Bethany K Terry1,2, Julia M McDonnell1

  • 1Shriners Hospitals Pediatrics Research Center, Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

Frontiers in cell and developmental biology
|October 30, 2023
PubMed
概括

马赛克多样化积症 (MVA) 基因Bub1B缺陷通过细胞死亡导致小头症. 即使没有P53,替代细胞死亡途径也会消除异常细胞,揭示出强大的细胞消除机制.

关键词:
这就是BubR1的意思.造成的DNA损伤是DNA损伤.皮层发育 皮层发育微头症是一个微头症.线粒分裂的分析分析.神经前代子的神经前代子在p53中,p53是什么?

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