在内脏疼痛中的nocebo效应:实验性随机对照疼痛研究"NoVis"的概念和设计
Jana Luisa Aulenkamp1,2, Adriane Icenhour3, Sigrid Elsenbruch2,3
1Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Frontiers in psychiatry
|October 30, 2023
概括
负面期望,或nocebo效应,显著影响内脏疼痛感知. 这项研究调查了负面指令和经验如何影响疼痛反应,为治疗慢性内脏疼痛障碍提供了洞察力.
科学领域:
- 心理学和神经科学 心理学和神经科学
- 胃肠病学 胃肠病学
- 疼痛研究 疼痛研究
背景情况:
- 心理因素,特别是期望,在肠-大脑相互作用 (DGBI) 障碍中影响慢性内脏疼痛.
- 诺塞博效应 (负面预期) 在DGBI中至关重要,但在内脏疼痛中很少被研究.
- 了解nocebo效应可以改善DGBI的预防和治疗策略.
研究的目的:
- 用多重威胁疼痛范式研究健康志愿者的nocebo效应的产生和持久性.
- 阐明负面期望的影响,由指令和/或经验引起,对内脏和体质疼痛.
- 为了比较负面指令与负面经验的有效性,以及它们对疼痛反应的综合影响.
主要方法:
- 一项实验性随机对照研究 ("NoVis") 具有受试者之间的设计.
- 四个实验组:负指令与控制,负经验与控制.
- 使用强度匹配的直肠膨胀 (内脏) 和热刺激 (体质),以及心理生理和神经内分泌的测量.
主要成果:
- 负面的期望,特别是当由指令和经验引起时,预计会显著放大疼痛反应.
- 这项研究旨在确定nocebo效应对内脏疼痛模式与体质疼痛模式的最大影响.
- 将评估负面期望对疼痛感知和相关压力,恐惧和焦虑标志物的影响.
结论:
- 诺塞博效应显著导致慢性内脏疼痛的产生和恶化.
- 了解nocebo机制可以改善DGBI和相关疾病的治疗结果.
- 这项研究提供了关于负面期望在疼痛病理生理学和治疗中的作用的关键见解.
关键词:
恐惧 恐惧 恐惧 恐惧肠-大脑轴 肠-大脑轴诺塞博效应 (nocebo效应) 是一种无效的疗法.身体性疼痛 身体性疼痛压力就是压力,压力就是压力.治疗期望 治疗期望这是一种内脏性过敏症 (visceral hyperalgesia).内脏疼痛是什么?内脏疼痛是什么更多相关视频
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