心脏参数更好地预测COVID-19住院患者的ICU入院和短期死亡率
Emrah Aksakal1, Sidar Ş Aydın1, Selim Aydemir1
1Cardiology, Erzurum City Hospital, Erzurum, TUR.
Cureus
|October 30, 2023
概括
这项研究发现,虽然许多血液标记物与COVID-19的结果有关,但心脏标记物如热素和脑性尿素 (BNP) 是重症监护室 (ICU) 入院和死亡率的最有效预测因素. 这些发现凸显了心脏评估在管理COVID-19患者中的重要性.
科学领域:
- 内部医学 内部医学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19是一种影响各种器官的多系统性疾病,需要在住院和随访期间监测各种生物化学参数.
- 了解血液参数的预后价值,包括肝/功能,炎症标志物和心脏标志物,对于管理COVID-19患者至关重要.
研究的目的:
- 调查各种血液参数与COVID-19患者的重症监护室 (ICU) 入院和死亡率之间的关系.
- 确定不良结果的独立预测因素,并评估COVID-19预后不同生物标志物的比较预测价值.
主要方法:
- 在2020年4月至2022年11月期间住院的5100名COVID-19患者的回顾性分析.
- 评估血液参数,包括肝/功能测试,乳酸,D-二分体,C反应蛋白 (CRP),淋巴细胞计数,费里丁,白蛋白,肌酸激酶-心肌带 (CK-MB),氨酸和脑性尿素 (BNP).
- 考克斯回归和接收器操作特征 (ROC) 曲线分析被用来确定独立的预测因子和预测准确性.
主要成果:
- 老年人和男性患者的死亡率和ICU入院率更高.
- 器官功能测试,血清参数,炎症标志物和心脏参数与不良结果有显著的关联.
- 乳酸盐,白蛋白,热素和BNP被确定为死亡率和ICU入院的独立预测因子,热素和BNP表现出卓越的预测能力.
结论:
- 虽然COVID-19影响多个系统,但心脏标记物 (热素和BNP) 对疾病过程和预后具有显著的预测价值,即使它不是主要是心脏疾病.
- 对各种血液参数进行全面评估是必不可少的,但心脏标志物在COVID-19患者中提供了更强大的严重结果的指标.
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