血清维生素D水平作为急性缺血性中风的风险因素和预后标志物:印度北部一个三级护理中心的病例对照研究
Kislaya Kamal1, Jay Tewari2, Vipin Bharti1
1Internal Medicine, King George's Medical University, Lucknow, IND.
Cureus
|October 30, 2023
概括
维生素D缺乏与急性缺血性中风的风险更高有关. 较低的维生素D水平与中风的严重程度增加和患者的治疗结果较差相关,这突显了它在预防中风方面的重要性.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 卒中仍然是全球主要的死亡原因之一.
- 关键的危险因素包括高血压,糖尿病和吸烟.
- 维生素D缺乏是中风的新兴危险因素.
研究的目的:
- 调查维生素D水平与急性缺血性中风之间的相关性.
- 评估维生素D状况与中风严重程度之间的关联.
- 评估维生素D对中风后功能结果的影响.
主要方法:
- 一项观察性病例控制研究,涉及150名患者 (75例,75例对照).
- 测量维生素D水平和国家卫生研究院中风量表 (NIHSS) 在入院时的得分.
- 使用修改的兰金尺度 (mRS) 评估功能结果.
主要成果:
- 高血压 (61.3%),糖尿病 (41.3%) 和吸烟 (37.3%) 是普遍存在的危险因素.
- 很大一部分患者表现出维生素D缺乏 (49.4%) 或缺乏 (30.6%).
- 发现维生素D充足度与中风发生率 (p=0.048) 之间,以及维生素D水平与NIHSS得分 (p=0.03) 之间存在显著的相关性.
结论:
- 越来越严重的维生素D缺乏与较高的死亡率和急性缺血性中风的较差结果有关.
- 维持足够的维生素D水平可能对预防中风和恢复至关重要.
- 需要进一步的研究来探索针对维生素D的治疗干预措施.
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