对于注意力缺陷多动性障碍 (ADHD) 的兴奋剂干预的不良影响:综合系统性审查
Ankita Nanda1, Lakshmi Sai Niharika Janga1, Hembashima G Sambe1
1Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
对注意力缺陷多动症 (ADHD) 的兴奋剂药物表现出轻微的副作用,如心率增加,但严重的心血管事件很少发生. 长期使用甲基胺似乎是安全的,尽管安非他命可能会增加精神病发作风险.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 注意缺陷多动症 (ADHD) 是一种常见的儿童精神疾病,影响生活质量.
- 刺激药物,包括甲基,对于管理ADHD症状至关重要.
- 对于ADHD患者长期使用兴奋剂的潜在不良反应存在担忧.
研究的目的:
- 在被诊断为ADHD的个体中,系统地审查长时间暴露于兴奋剂药物的负面影响.
- 分析在ADHD管理中与甲基酸盐和安非他命相关的潜在不良影响.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 精心搜索数据库,并预先定义了包含和排除的标准.
- 对13项关于ADHD兴奋剂药物效应的研究进行分析.
主要成果:
- 随着兴奋剂的使用,特别是安非他命,观察到血压和心率的轻微增加.
- 没有报告任何严重的心血管事件.
- 长期使用甲基酸没有显示严重的神经精神疾病后果;安非他命与精神病发作风险增加有关.
- 常见的胃肠道副作用包括食欲下降和胃痛.
- 关于眼睛异常和与生长有关的影响的不确定的发现.
结论:
- 对ADHD的刺激药物通常会导致可控的,轻微的不良结果.
- 仔细的监测和进一步的研究对于充分了解即时和长期影响至关重要.
- 虽然甲基化物长期看起来相对安全,但安非他命使用需要更密切地观察神经精神疾病的影响.
更多相关视频
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
13:09Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
Published on: April 1, 2018
相关概念视频
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
