没有证据表明结性脊柱炎和心血管疾病之间存在因果关系:一项两样本的门德尔随机化研究
Yan Zhong1, YingWen Chen2, XinYue Zhang3
1College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Frontiers in cardiovascular medicine
|October 30, 2023
概括
这项研究发现,结性脊髓炎 (AS) 和心血管疾病 (CVD) 之间没有因果关系. 门德尔随机分析证实,AS不会增加患心血管疾病的风险.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
背景情况:
- 观察性研究表明,结性脊柱炎 (AS) 与心血管疾病 (CVD) 风险增加之间存在潜在联系.
- 以前的研究受到混因素和潜在的反向因果关系的限制.
- 门德尔随机化 (MR) 提供了一个强大的方法来调查因果关系.
研究的目的:
- 使用孟德尔的随机化方法来确定结性脊髓炎 (AS) 和心血管疾病 (CVD) 之间的因果关系.
- 克服观察性研究的局限性,包括混和反向因果关系.
主要方法:
- 一项大规模的门德尔随机化研究,涉及9069名AS个体和509,093名对照.
- 利用总结统计数据和使用逆方差加权 (IVW) 和加权中位数方法进行因果推理.
- 进行了 CAUSE 分析和反向门德尔随机化来加强发现.
主要成果:
- 在AS和整体心血管疾病或特定亚型 (心力衰竭,心肌梗塞,膜心脏病,缺血性心脏病,静脉血栓栓塞) 之间没有发现因果关系的证据.
- 动脉硬度指数也显示,与AS没有因果关系.
- 在不同的MR方法 (IVW,加权中位数, CAUSE) 中观察到一致的结果,没有发现显著的异质性或性.
结论:
- 这项门德尔随机化研究没有支持结性脊柱炎和心血管疾病之间的因果关系.
- 研究结果表明,以前观察到的关联可能是由于混或其他非因果因素.
- 需要进一步的研究来充分阐明AS和心血管健康之间的复杂关系.
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