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长期临床结果对于无法穿越专利卵巢孔的患者
Yonghoon Shin1, Albert Youngwoo Jang2, Yoonsun Won2
1Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Frontiers in cardiovascular medicine
|October 30, 2023
概括
患有无法穿越的圆孔 (PFO) 患者的结果与那些成功关闭PFO患者的结果相似. 这一发现表明,无论手术是否成功,密码性中风患者的长期预后都是相似的.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 干预心脏病学 干预心脏病学
背景情况:
- 专利卵孔 (PFO) 关闭是一种预防反复发生的密码性中风的策略.
- 试图关闭后无法穿越PFO的患者的长期预后尚未确立.
研究的目的:
- 为了比较PFO无法穿越的患者的长期预后与那些经历了成功PFO关闭的患者.
- 为了评估患有高等级PFO突变的患者的结果.
主要方法:
- 对245名接受PFO关闭以预防中风/TIA的患者的回顾性分析 (2010年4月-2022年3月).
- 患者被分为"无法穿越的PFO" (n=82) 和"成功关闭PFO" (n=163) 组.
- 主要结局:复杂的复发性中风或TIA. 二次结局包括中风,TIA,全因死亡.
主要成果:
- 在无法穿越PFO组 (2.4%) 和成功闭合组 (4.9%) 之间,中风或TIA复发没有显著差异 (HR 1.44;95% CI 0.30-6.81;P=0.647).
- 在成功关闭组 (62.0%) 与无法穿越的PFO组 (34.1%) 相比,大型分流更为普遍.
- 根据基线特征,RoPE得分或分离等级的子组分析显示,中风或TIA发生率没有差异.
结论:
- 不能穿越PFO的患者的临床结果与成功完成PFO关闭的患者相似.
- 这表明,不可穿越的PFO可能不一定预示着关于中风或TIA复发的更糟糕的长期预后.
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