在周围神经系统恒温,疾病和临床前治疗中的神经元-施瓦恩细胞相互作用
Julia Teixeira Oliveira1, Christopher Yanick1, Nicolas Wein2,3
1Department of Neurology, University of Miami, Miami, FL, United States.
Frontiers in cellular neuroscience
|October 30, 2023
概括
施万细胞 (SCs) 对外围神经健康和修复至关重要. 本综述探讨了SC-axon相互作用和神经病变和神经损伤的治疗策略,强调了体外和体外模型.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 再生医学是一种再生医学.
背景情况:
- 施万细胞 (SCs) 对于周围神经系统 (PNS) 恒温和轴突支持至关重要.
- 由于遗传突变或疾病,功能障碍的SCs会损害神经再生,导致诸如Charcot-Marie-Tooth病之类的神经病变.
- 了解SC-axon在健康,伤害和疾病中的相互作用,对于开发有效的治疗方法至关重要.
研究的目的:
- 审查施万细胞在外围神经修复和再生中的作用.
- 讨论体外和体内模型的实用性和挑战,以研究周围神经损伤 (PNI) 和神经病变.
- 总结目前用于PNS修复的临床前治疗策略.
主要方法:
- 关于施万细胞生物学,外围神经病变和神经损伤模型的现有文献的综述.
- 分析用于评估治疗点的体外和体内实验系统.
- 讨论基于细胞的策略,包括直接转换和多能干细胞衍生的SCs.
主要成果:
- 施万细胞功能障碍是各种外围神经病变的基础,并阻碍神经再生.
- 在体外和体外模型是研究治疗点的有价值的工具,但在复制SC神经元相互作用方面仍然存在挑战.
- 临床前研究正在探索转基因,药物和化合物,以潜在的临床转化.
结论:
- 有效的再生需要在各种条件下更深入地了解SC-axon相互作用.
- 从替代来源产生功能性SC的进展显示出有希望.
- 持续的临床前研究对于开发治疗外围神经疾病的新疗法至关重要.
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