相关的生物化学和血液学标记在COVID-19严重性预测中的作用
Anit Lamichhane1,2, Sushant Pokhrel1, Tika Bahadur Thapa2
1Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal.
Advances in medicine
|October 30, 2023
概括
生物标志物如D-二聚合物,CRP,LDH和中性粒细胞数量可以预测COVID-19的严重程度. 这些实验室参数的早期分析有助于预测疾病进展并为干预措施提供信息.
科学领域:
- 临床医学 临床医学
- 生物化学 生物化学
- 血液学 血液学 血液学
背景情况:
- 由于COVID-19的流行,需要对疾病进展和有效干预措施进行研究.
- 生物标志物对于了解COVID-19的严重程度和指导治疗策略至关重要.
研究的目的:
- 评估实验室参数与COVID-19严重程度之间的相关性.
- 为了确定严重的COVID-19感染的预测生物标志物.
主要方法:
- 191名COVID-19患者根据临床结果被分为严重和非严重的组.
- 分析了实验室参数,包括炎症标志物 (LDH,D-二次体,CRP,费里丁),CBC,LFT和RFT.
- 用二进制物流回归和ROC曲线分析来识别风险因素和评估预测值.
主要成果:
- 高龄和并发性疾病 (CKD,HTN,DM,COPD,肺炎) 与严重的COVID-19有关.
- 严重程度的重要独立风险因素包括D-二聚合物,CRP,LDH,SGPT,中性粒细胞计数和LMR.
- D-二次体显示了预测严重程度的最高AUC (0.874),并确定了几个参数的特定切断值.
结论:
- 生物化学和血液学参数,具有确定的切断值,可以预测COVID-19的严重程度.
- 生物标志物如D-二聚合物,CRP,LDH,ALT和中性粒细胞计数对于预测疾病严重程度非常有价值.
- 对这些标记物的及时分析能够预测COVID-19进展的早期预测.
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