肺腺癌在长期佩姆布利祖马布治疗期间接种SARS-CoV-2疫苗后的尺寸减小:一个病例报告
Koki Fujii1, Kensuke Fukuda1, Masanori Kawakami1
1Department of Respiratory Medicine, The University of Tokyo Hospital, Tokyo, Japan.
Case reports in oncology
|October 30, 2023
概括
这项案例研究表明,癌症免疫力在长期免疫检查点抑制剂治疗期间可能会持续存在. 在肺腺癌患者中使用 pembrolizumab 治疗可能允许进一步的免疫激活,即使在接种了 COVID-19 疫苗后.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 肺腺癌是癌症相关死亡的一个重要原因.
- 免疫检查点抑制剂 (ICI) 如 pembrolizumab 已经彻底改变了癌症治疗.
- 癌症免疫,ICI和疫苗接种之间的相互作用需要进一步研究.
研究的目的:
- 报告一个用 pembrolizumab 治疗的晚期肺腺癌病例.
- 探索长期ICI治疗期间抗瘤免疫的潜在持久性.
- 评估SARS-CoV-2疫苗接种对接受ICI治疗的患者的影响.
主要方法:
- 一名患有4B期肺腺癌的患者接受了pembrolizumab.
- 瘤特征包括PD-L1阳性 (100%) 和高瘤突变负担.
- 患者在治疗期间接受了两剂BNT162b2 SARS-CoV-2疫苗.
主要成果:
- 在 pembrolizumab 给药后观察到部分反应.
- 疫苗接种后注意到过渡性周围瘤巩固,它得到了解决.
- 在接种疫苗后4个月内观察到持续的瘤缩.
- 在延长ICI治疗期间,患者保持了抗瘤免疫反应.
结论:
- 这一案例表明,在长时间的ICI治疗期间,癌症免疫力可以持续存在.
- 在肺腺癌中, pembrolizumab 的疗效可能会持续,并有可能激活免疫系统.
- 接种SARS-CoV-2疫苗似乎不会对这个患者的抗瘤反应产生负面影响.
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